For several thousand years, farmers have been altering the genetic makeup of the crops they grow. Human selection for features such as faster growth, larger seeds or sweeter fruits has dramatically changed domesticated plant species compared to their wild relatives. Remarkably, many of our modern crops were developed by people who lacked an understanding of the scientific basis of plant breeding.
In the late 1920s, researchers discovered that they could greatly increase the number of these variations or mutations by exposing plants to X-rays. "Mutation breeding" accelerated after World War II, when the techniques of the nuclear age became widely available. Plants were exposed to gamma rays, protons, neutrons, alpha particles, and beta particles to see if these would induce useful mutations. Chemicals, too, such as sodium azide and ethyl methanesulphonate, were used to cause mutations.
http://cls.casa.colostate.edu/transgeniccrops/history.html - Raecelynn Besa
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